Install Arduino. Select serial port from selection. There may be two options
dev/tty/usbserial
dev/cu/usbserial
select dev/cu/usbserial. This does not look for hardware signal for handshake.
2. Arduino on MAC works in 32 bit. To open application in 32 bit, press CTRL and left click on icon and select GET INFO.
Under get info, there is a box named as "Open in 32 bit Mode" check that box.

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